Control of the Initiation of DNA Synthesis in 3T3 Cells: Serum Factors
Author(s) -
Robert W. Holley,
Josephine A. Kiernan
Publication year - 1974
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.71.7.2908
Subject(s) - dna synthesis , 3t3 cells , dna , fibroblast , biology , microbiology and biotechnology , chemistry , in vitro , cell culture , biochemistry , genetics , transfection
The initiation of DNA synthesis in 3T3 cells can be controlled by a variety of different factors. Cells that are quiescent because of limited serum initiate DNA synthesis in response to the fibroblast growth factor of Gospodarowicz, to insulin, and to dexamethasone, as well as to other, unidentified biological materials. Interactions are seen between the effects of different factors.
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