Open AccessEstrogen-Related Increases in Uterine Guanosine 3′:5′-Cyclic Monophosphate Levels
Author(s) -
Frederick A. Kuehl,
Edward A. Ham,
Mary E. Zanetti,
Cynthia Sanford,
Susan E. Nicol,
Nelson D. Goldberg
Publication year - 1974
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.71.5.1866
Subject(s) - diethylstilbestrol , estrogen , endocrinology , medicine , estradiol benzoate , guanosine , estrous cycle , cyclic gmp , ovariectomized rat , endogeny , chemistry , cyclic guanosine monophosphate , cyclic nucleotide , biology , nucleotide , biochemistry , nitric oxide , gene
Endogenous uterine cyclic GMP and cyclic AMP concentrations were monitored at each stage of the estrus cycle; cyclic GMP concentrations were found to be highest and cyclic AMP concentrations lowest during proestrus when plasma estrogen levels have been shown to be maximal. After administration of estradiol-17β or diethylstilbestrol, the concentrations of uterine cyclic GMP in ovariectomized rats underwent a progressive and significant elevation and the levels of cyclic AMP declined significantly below control values when near maximal accumulation of tissue cyclic GMP was achieved. The increase in uterine cyclic GMP concentrations produced by estradiol benzoate administration was prevented when progesterone and the estrogen were co-administered. These results raise the possibility that an enhanced cellular accumulation of cyclic GMP may be involved in the expression of some of the actions of estrogen in uterine tissue.