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Possible age-related deterioration in the efficacy of DNA repair was investigated in a complement of non-dividing mammalian cells which is not replenished during the lifetime of the animal. Internal granular-layer neurons were extracted from the cerebella of beagle dogs, aged from 7 weeks to 13 years, following exposure in situ to 4700 rads of collimated (60)Co gamma rays. The alkaline sucrose-gradient sedimentation profiles obtained from the DNA of those neurons after various post-irradiation periods in situ can be interpreted: (a) that there is not an age-associated decrease in the ability of the cells to rejoin the single-strand breaks induced by radiation, but (b) that there may be an age-associated decline in the size of the DNA-containing species which can be extracted from unirradiated cells. The latter effect may reflect normal aging of the cerebellum.

On the Possibility That DNA Repair Is Related to Age in Non-Dividing Cells