The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture | Zendy

B. Halpern | Zendy; Brian R. Clark | Zendy; Dorothy Hardy | Zendy; Richard M. Halpern | Zendy; Roberts A. Smith | Zendy

Open Access

The Effect of Replacement of Methionine by Homocystine on Survival of Malignant and Normal Adult Mammalian Cells in Culture

Author(s) -

B. Halpern,

Brian R. Clark,

Dorothy Hardy,

Richard M. Halpern,

Roberts A. Smith

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.4.1133

Subject(s) - methionine , biochemistry , tissue culture , malignant cells , biology , cell culture , folic acid , amino acid , chemistry , in vitro , medicine , genetics , cancer

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

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