The Presence of the Lucké Herpesvirus Genome in Induced Tadpole Tumors and Its Oncogenicity: Koch-Henle Postulates Fulfilled | Zendy

Robert F. Naegele | Zendy; Allan Granoff | Zendy; R. W. Darlington | Zendy

Open Access

The Presence of the Lucké Herpesvirus Genome in Induced Tadpole Tumors and Its Oncogenicity: Koch-Henle Postulates Fulfilled

Author(s) -

Robert F. Naegele,

Allan Granoff,

R. W. Darlington

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.3.830

Subject(s) - luck , biology , in vitro , virus , genome , virology , genetics , gene , philosophy , theology

Herpesvirus extracted from a naturally occurring frog renal carcinoma (Lucké tumor) induced virus-free Lucké tumors in developing frogs. Herpesvirus recovered from an induced tumor after incubation at low temperature of tumor fragments culturedin vitro was oncogenic when injected into developing frog embryos. With the exception of the “pure culture” requirement, this experiment fulfills Koch-Henle postulates for the identification of the causative agent of the Lucké tumor.

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