Embryonic Cell Aggregation: Kinetics and Specificity of Binding of Enhancing Factors | Zendy

Janne Balsamo | Zendy; Jack Lilien | Zendy

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Embryonic Cell Aggregation: Kinetics and Specificity of Binding of Enhancing Factors

Author(s) -

Janne Balsamo,

Jack Lilien

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.3.727

Subject(s) - kinetics , macromolecule , embryonic stem cell , receptor–ligand kinetics , binding site , cell , biophysics , microbiology and biotechnology , chemistry , plasma protein binding , biology , biochemistry , receptor , physics , quantum mechanics , gene

A new assay for tissue-type-specific adhesive macromolecules is described. This assay measures the binding to whole cells of radioactive macromolecules in aggregation-enhancing supernatants. We show for two tissue types, embryonic chick neural retina and cerebrum, that binding is tissue-type specific. Specific binding can be distinguished from nonspecific binding by its sensitivity to displacement with horse serum and by the kinetics of binding. Specific binding appears to be a cooperative phenomenon.

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