The Presence of I-Region-Associated Antigens on B Cells in Molecules Distinct from Immunoglobulin and H-2K and H-2D | Zendy

Emil R. Unanue | Zendy; Martin E. Dorf | Zendy; Chella S. David | Zendy; Baruj Benacerraf | Zendy

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The Presence of I-Region-Associated Antigens on B Cells in Molecules Distinct from Immunoglobulin and H-2K and H-2D

Author(s) -

Emil R. Unanue,

Martin E. Dorf,

Chella S. David,

Baruj Benacerraf

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.12.5014

Subject(s) - antigen , surface immunoglobulin , antibody , immunofluorescence , microbiology and biotechnology , biology , immunoglobulin g , pan t antigens , incubation , chemistry , b cell , immunology , monoclonal antibody , biochemistry

The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The complexes of I-anti-I-region-associated antigens were found to be distributed throughout the lymphocyte surface both at 4° and 37°. In about two-thirds of the lymphocytes the complexes redistributed into caps after incubation with a second ligand (an anti-mouse immunoglobulin). The I-region specificities were in molecules distinct from immunoglobulin or from the molecules coded by the H-2K and H-2D regions.

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