A Pyruvate-Valine Enzyme Complex that is Dependent upon the Metabolic State of the Mitochondria | Zendy

Arloa Bergquist | Zendy; E. A. Eakin | Zendy; D.K. Murali | Zendy; R. P. Wagner | Zendy

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A Pyruvate-Valine Enzyme Complex that is Dependent upon the Metabolic State of the Mitochondria

Author(s) -

Arloa Bergquist,

E. A. Eakin,

D.K. Murali,

R. P. Wagner

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.11.4352

Subject(s) - neurospora crassa , digitonin , biochemistry , valine , enzyme , mitochondrion , biology , biosynthesis , isoleucine , neurospora , chemistry , amino acid , leucine , gene , mutant

Data are presented suggesting that intactNeurospora crassa mitochondria contain an enzyme complex incorporating five enzymes necessary for the biosynthesis of isoleucine and valine. The functional integrity and stability of the complex has been shown to be dependent on the metabolic state of the mitochondria. The complex has been solubilized by digitonin and has an approximate molecular weight of 400,000.

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