Open AccessAntiinflammatory Effects of Murine Malignant Cells
Author(s) -
Robert M. Fauve,
Brigitte Hévin,
Hedwig Jacob,
JeanLuc Gaillard,
Fran cois Jacob
Publication year - 1974
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.71.10.4052
Subject(s) - syngenic , teratocarcinoma , inflammation , biology , immune system , immunology , cancer research , trophoblast , in vivo , in vitro , microbiology and biotechnology , cellular differentiation , biochemistry , pregnancy , fetus , genetics , gene , placenta
Development of teratocarcinoma does not impair immunization of mice againstListeria monocytogenes . Endotoxin injection a short time before tumor cell inoculation allows the growth of teratocarcinoma in non syngenic mice despite immune stimulation. In contrast with this absence of impaired systematic immunity, teratocarcinoma cells were found to repulse macrophagesin vitro . This effect on macrophages was also found with three other malignant cells and with trophoblast cells.In vivo , teratocarcinoma cells were found to impair local inflammation. These cells and other malignant cells are able to produce a compound(s) of molecular weight between 103 and 104 , which prevents inflammatory reaction. These results suggest that mouse teratocarcinomas and other tumors by-pass the host immunological system of surveillance by at least two mechanisms: a direct toxic effect on macrophages and the release of an inhibitor of inflammation. The possible relations between these properties of malignant cells and physiological functions of trophoblast are discussed.