Open AccessLocation of the Spike Glycoproteins in the Semliki Forest Virus Membrane
Author(s) -
Henrik Garoff,
Kai Simons
Publication year - 1974
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.71.10.3988
Subject(s) - semliki forest virus , glycoprotein , virus , biology , virology , spike (software development) , alphavirus , viral membrane , chemistry , biochemistry , viral envelope , rna , economics , management , gene
Labeling experiments with formyl-[(35)S]-methionyl sulfone methylphosphate and crosslinking studies with dimethylsuberimidate suggest that the spike glycoproteins of Semliki Forest virus extend through the viral membrane into close contact with the nucleocapsid. Based on this finding, we present a mechanism for the formation of virus-specific patches in the host cell plasma membrane during virus assembly.
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