Activation of Transcription of hut DNA by Glutamine Synthetase | Zendy

B Tyler | Zendy; Albert B. DeLeo | Zendy; Boris Magasanik | Zendy

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Activation of Transcription of hut DNA by Glutamine Synthetase

Author(s) -

B Tyler,

Albert B. DeLeo,

Boris Magasanik

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.1.225

Subject(s) - glutamine synthetase , operon , catabolite repression , biochemistry , transcription (linguistics) , enzyme , glutamine , dna , biology , chemistry , microbiology and biotechnology , escherichia coli , gene , amino acid , linguistics , philosophy , mutant

The correct transcription of thehut (histidine utilization) operon DNA ofSalmonella typhimurium requires activation either by 3′:5′-cyclic adenosine monophosphate and catabolite-activating protein or by nonadenylylated glutamine synthetase (EC 6.3.1.2.). Thus, glutamine synthetase plays a regulatory role distinct from its enzymatic function.

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