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The correct transcription of thehut (histidine utilization) operon DNA ofSalmonella typhimurium requires activation either by 3′:5′-cyclic adenosine monophosphate and catabolite-activating protein or by nonadenylylated glutamine synthetase (EC 6.3.1.2.). Thus, glutamine synthetase plays a regulatory role distinct from its enzymatic function.

Activation of Transcription of hut DNA by Glutamine Synthetase