Transformation of Cultured Mammalian Cells by Viable Herpes Simplex Virus Subtypes 1 and 2 | Zendy

B. Garfinkle | Zendy; B.R. McAuslan | Zendy

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Transformation of Cultured Mammalian Cells by Viable Herpes Simplex Virus Subtypes 1 and 2

Author(s) -

B. Garfinkle,

B.R. McAuslan

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.1.220

Subject(s) - rous sarcoma virus , herpes simplex virus , virology , thymidine kinase , transformation (genetics) , biology , virus , viral transformation , enzyme , antigen , gene , genetics , biochemistry

A continuous line of rodent cells carrying the genome of the Rous sarcoma virus was stably transformed by exposure to viable herpes simplex virus of either subtype 1 or 2. Transformation was accompanied by alteration of morphology, growth characteristics, acquisition of a thymidine kinase activity (EC 2.7.1.21) resembling the corresponding specific activity of the enzyme in the herpes simplex virus, and capacity to express continuously some antigens specific for herpes simplex virus.

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