Restoration of the Conversion of Desmosterol to Cholesterol in L-Cells after Hybridization with Human Fibroblasts | Zendy

Carlo M. Croce | Zendy; Irene R. Kieba | Zendy; Hilary Koprowski | Zendy; Marina Molino | Zendy; George H. Rothblat | Zendy

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Restoration of the Conversion of Desmosterol to Cholesterol in L-Cells after Hybridization with Human Fibroblasts

Author(s) -

Carlo M. Croce,

Irene R. Kieba,

Hilary Koprowski,

Marina Molino,

George H. Rothblat

Publication year - 1974

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.71.1.110

Subject(s) - desmosterol , sterol , cholesterol , biochemistry , chemistry , biology , microbiology and biotechnology

Hybrids between different human cells (which synthesize cholesterol) and mouse cells (whose end-product of sterol synthesis is desmosterol) were analyzed for the ability to convert desmosterol to cholesterol. Conversion of [14 C]desmosterol to cholesterol and incorporation of [14 C]acetate into the end-product sterol were studied in the parental and hybrid cells. Concordant segregation of the conversion of desmosterol to cholesterol and the human chromosome F-20 was observed.

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