Open AccessGlia-Induced Morphological Differentiation in Neuroblastoma Cells
Author(s) -
Denis Monard,
Frank Solomon,
Magda Rentsch,
Reinhard Gysin
Publication year - 1973
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.6.1894
Subject(s) - intracellular , neuroblastoma , cellular differentiation , microbiology and biotechnology , adenosine , cell culture , biology , cell growth , chemistry , biochemistry , genetics , gene
Glial cells release a factor into their culture medium that induces a high degree of morphological differentiation in neuroblastoma cells under normal growth conditions. This phenomenon is not correlated with a change in intracellular adenosine 3′:5′-cyclic monophosphate or in the rate of cell growth. Media from other cell lines tested induce less morphological differentiation or have no effect.