Open AccessThe Role of the Histocompatibility-2-Linked Ss-Slp Region in the Control of Mouse Complement
Author(s) -
Peter Démant,
J Capková,
E Hinzová,
B Vorácová
Publication year - 1973
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.3.863
Subject(s) - congenic , biology , allele , genotype , major histocompatibility complex , histocompatibility , complement system , gene , complement (music) , genetics , strain (injury) , complement control protein , haplotype , inbred strain , recombinant dna , microbiology and biotechnology , antigen , antibody , complement factor i , phenotype , human leukocyte antigen , complementation , anatomy
TheSs-Slp region of the mouse genome is located between the two loci,H-2K andH-2D , of the major histocompatibility system. It controls the level of a serologically detectable serum globulin, the Ss protein, and its allotypic forms, Slpa and Slpo . Evidence is presented that theSs-Slp region is involved in control of the complement system. Mice of congenic resistant strains differing only at theH-2 gene complex show differences in complement levels. A comparison ofH-2 recombinants demonstrated that complement level correlates with theSs-Slp genotype and not with theH-2K, H-2D , orIr genotypes. Among the 13 congenic strains tested, those with theSs h Slp a allele had higher complement levels than those with theSs h Slp o orSs l Slp o alleles. Mice with recombinantH-2 haplotypes had complement levels similar to those of the parental strain that provided theSs-Slp segment. It was also shown that anti-Ss serum inhibits complement activity of mouse serumin vitro .
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