Demonstration and Distribution of Phenylethanolamine in Brain and Other Tissues | Zendy

Juan M. Saavedra | Zendy; Julius Axelrod | Zendy

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Demonstration and Distribution of Phenylethanolamine in Brain and Other Tissues

Author(s) -

Juan M. Saavedra,

Julius Axelrod

Publication year - 1973

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.70.3.769

Subject(s) - phenylethanolamine , phenylethanolamine n methyltransferase , endocrinology , medicine , chemistry , monoamine oxidase , hypothalamus , norepinephrine , dopamine , enzyme , biology , biochemistry , tyrosine hydroxylase

A specific and sensitive assay for phenylethanolamine in tissues is described. By this assay, phenylethanolamine was detected in many peripheral tissues and brains of rats. It is unequally distributed in rat brain, with the highest concentration present in hypothalamus and midbrain. Concentrations of brain phenylethanolamine were elevated after administration of phenylethylamine, phenylalanine, p-chlorophenylalanine, and monoamine oxidase inhibitors and decreased after administration of dopamine-beta-hydroxylase inhibitors. Denervation of sympathetic nerves caused a moderate fall in phenylethanolamine concentrations. These results indicate that phenylethanolamine is synthesized intraneuronally from phenylalanine and phenylethylamine, but that only part of the phenylethanolamine is stored in sympathetic nerves.

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