Protective Effect of Ascorbic Acid on Hepatotoxicity Caused by Sodium Nitrite Plus Aminopyrine | Zendy

Jerome J. Kamm | Zendy; Theodore Dashman | Zendy; Allan H. Conney | Zendy; J.J. Burns | Zendy

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Protective Effect of Ascorbic Acid on Hepatotoxicity Caused by Sodium Nitrite Plus Aminopyrine

Author(s) -

Jerome J. Kamm,

Theodore Dashman,

Allan H. Conney,

J.J. Burns

Publication year - 1973

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.70.3.747

Subject(s) - dehydroascorbic acid , sodium nitrite , ascorbic acid , chemistry , sodium ascorbate , nitrite , sodium , pharmacology , vitamin c , biochemistry , food science , medicine , organic chemistry , nitrate

The oral treatment of rats with sodium ascorbate in combination with sodium nitrite and aminopyrine prevents the rise in serum alanine aminotransferase (EC 2.6.1.2) observed when nitrite and aminopyrine are given alone. Ascorbic acid also affords protection, whereas dehydroascorbic acid exerts no protective effect.

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