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Crossreactive Antigens on Human Cells Infected with Rauscher Leukemia Virus and on Human Acute Leukemia Cells
Author(s) -
Dean L. Mann,
Roger H. Halterman,
Brigid G. Leventhal
Publication year - 1973
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.2.495
Subject(s) - antigen , leukemia , virology , antiserum , biology , lymphoma , cell culture , virus , microbiology and biotechnology , immunology , genetics
A water-soluble component of membranes of cells from a Burkitt's lymphoma cultured cell line was used to develop an antiserum that detects an antigen(s) on acute leukemia cells. This antiserum did not react with nonlymphoid cultured cell lines except for human embryonic kidney cells infected with the Rauscher murine leukemia virus. Absorption studies demonstrated this antigen to be crossreactive with the antigen detected on the human acute leukemia cells.

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