Open AccessEffect of Stimulation of the Host Defense System by Coenzyme Q 10 on Dibenzpyrene-Induced Tumors and Infection with Friend Leukemia Virus in Mice
Author(s) -
Emile G. Bliznakov
Publication year - 1973
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.2.390
Subject(s) - plasmodium berghei , parasitemia , coenzyme q – cytochrome c reductase , biology , leukemia , stimulation , virus , chloroquine , immunology , malaria , endocrinology , apoptosis , biochemistry , cytochrome c , plasmodium falciparum
Members of the coenzyme Q group increase the phagocytic activity in rats, as measured by the carbon clearance technique, and increase the hemolytic antibody formation in mice. In addition, prior treatment with low doses of chloroquine hydrochloride combined with coenzyme Q10 results in increased numbers of survivors, prolonged survival time, and reduced parasitemia in blood-transferredPlasmodium berghei infection in miceIn an extension of these studies, using emulsions of coenzyme Q10 , I demonstrated the following effects on two tumor systems in mice: (i ) Treatment with coenzyme Q10 decreased splenomegaly and hepatomegaly and increased the number of surviving mice infected with Friend leukemia virus. (ii ) Treatment with coenzyme Q10 reduced the percentage of mice with tumors, increased the number of survivors, and reduced the tumor size in mice with tumors induced by 3,4,9,10-dibenzpyrene. The effect on both tumor systems was dose-dependent. These studies support the hypothesis that the host defense system plays a definitive role in the defense of the host against invasion by various agents, including neoplasia.