Open AccessBiological Activities of Synthetic Peptides Corresponding to Fragments of and to the Entire Sequence of the Vasoactive Intestinal Peptide
Author(s) -
Miklos Bodanszky,
Yakir S. Klausner,
Sami I. Said
Publication year - 1973
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.2.382
Subject(s) - vasoactive intestinal peptide , vasoactive , sequence (biology) , peptide , peptide sequence , biological activity , chemistry , biology , biochemistry , polypeptide chain , neuropeptide , amino acid , in vitro , endocrinology , receptor , gene
An octacosapeptide with the entire sequence proposed for the newly isolated vasoactive intestinal polypeptide was synthesized and had the expected biological properties. Synthetic peptides corresponding to the C-terminal hendeca-, tetradeca-, pentadeca-, and docosapeptide sequences of the vasoactive intestinal polypeptide showed activities that increased with increasing chain length.