Open AccessMultiple Common Properties of Human β 2 -Microglobulin and the Common Portion Fragment Derived from HL-A Antigen Molecules
Author(s) -
K Nakamuro,
Nobutaka Tanigaki,
David Pressman
Publication year - 1973
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.70.10.2863
Subject(s) - beta 2 microglobulin , fragment (logic) , antigen , biology , molecule , chemistry , computational biology , microbiology and biotechnology , genetics , immunology , computer science , organic chemistry , programming language
11,000-Dalton common portion fragments derived from HL-A antigen molecules were isolated and found to have a significantly high homology to β2 -microglobulin in amino-acid composition. Common portion fragments are also very similar to β2 -microglobulin with respect to molecular size, charge, and distribution in tissues. Moreover, both are found in the spent culture media of human cell lines and in human plasma and urine. Thus it appears that β2 -microglobulin may well be the same substance as the common portion fragment of HL-A antigen molecules.
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