Open AccessIdentification of an Antigen from Normal Human Tissue That Crossreacts with the Carcinoembryonic Antigen
Author(s) -
S. von Kleist,
G. Chavanel,
P Burtin
Publication year - 1972
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.69.9.2492
Subject(s) - carcinoembryonic antigen , antigen , ouchterlony double immunodiffusion , glycoprotein , biology , immunodiffusion , microbiology and biotechnology , immunology , chemistry , cancer , genetics , antiserum
A glycoprotein present in normal human tissue is characterized that is neither organ- nor tumor-specific (nonspecific crossreacting antigen) and that crossreacts (by the Ouchterlony double-diffusion technique) with the carcinoembryonic antigen. This immunological relationship indicates common determinants on the molecules of both antigens. We demonstrate that the nonspecific crossreacting antigen is not a fragment of the carcinoembryonic antigen molecule.