Blocking by Histones of Accessibility to DNA in Chromatin | Zendy

A. E. Mirsky | Zendy; B. D. Silverman | Zendy

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Blocking by Histones of Accessibility to DNA in Chromatin

Author(s) -

A. E. Mirsky,

B. D. Silverman

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.8.2115

Subject(s) - histone , chromatin , dna , histone modifying enzymes , polymerase , dna polymerase , microbiology and biotechnology , biology , biochemistry , chemistry , histone h2a

The effect of histones on accessibility of DNA to DNase in chromatin of thymus nuclei has been studied by selective extraction of either lysine-rich or arginine-rich histones. It was found that all histones block accessibility but that, weight for weight, lysine-rich histones block much more effectively than do arginine-rich histones. We point to the contrast between accessibility of DNA to DNase and of DNA to RNA polymerase, and to what may be the similarity between accessibility to DNase and DNA polymerase.

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