Open AccessCorrelation of Messenger RNA Function with Adenylate-Rich Segments in the Genomes of Single-Stranded RNA Viruses
Author(s) -
Robert E. Johnston,
Henry R. Bose
Publication year - 1972
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.69.6.1514
Subject(s) - sindbis virus , oligonucleotide , rna , genome , vesicular stomatitis virus , biology , virology , virus , microbiology and biotechnology , dna , gene , genetics
Oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand RNA viruses, Sindbis and Columbia SK. Such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. The adenylate-rich oligonucleotides from Sindbis and Columbia SK viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate.