Activation of Leukemia Viruses by Graft-Versus-Host and Mixed Lymphocyte Reactions In Vitro | Zendy

Martin Hirsch | Zendy; S M Phillips | Zendy; Catherine Solnik | Zendy; Paul H. Black | Zendy; Robert S. Schwartz | Zendy; Charles B. Carpenter | Zendy

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Activation of Leukemia Viruses by Graft-Versus-Host and Mixed Lymphocyte Reactions In Vitro

Author(s) -

Martin Hirsch,

S M Phillips,

Catherine Solnik,

Paul H. Black,

Robert S. Schwartz,

Charles B. Carpenter

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.5.1069

Subject(s) - leukemia , in vitro , host (biology) , virology , lymphocyte activation , graft vs host reaction , lymphocyte , immunology , biology , chemistry , immune system , genetics , bone marrow , bone marrow transplantation , t cell

Spleen cells from BALB/c or CAF(1) mice released little or no detectable leukemia virus when cultured 2-7 days in vitro. In contrast, spleen cells of CAF(1) mice previously inoculated with parental BALB/c spleen cells released leukemia viruses in 10 of 11 cases studied. Cultures of a mixture of spleen cells from normal BALB/c and CAF(1) mice also contained leukemia viruses. Phytohemagglutinin induced the transformation of lymphocytes in cultures of CAF(1) or BALB/c spleen cells, but this transformation did not activate leukemia viruses. It is concluded that mixed lymphocyte cultures in vitro, just as graft-versus-host reactions in vivo, can activate leukemia viruses that are normally present in a repressed form. This activation is not solely a function of lymphocyte transformation. The activated mouse leukemia virus may subsequently account for the observed high incidence of neoplasia in graft-versus-host disease.

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