Enduring Behavioral Changes in Rats with Experimental Phenylketonuria | Zendy

Arnold E. Andersen | Zendy; Gordon Guroff | Zendy

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Enduring Behavioral Changes in Rats with Experimental Phenylketonuria

Author(s) -

Arnold E. Andersen,

Gordon Guroff

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.4.863

Subject(s) - phenylalanine , tyrosine , phenylalanine hydroxylase , phenylketonurias , tyrosine hydroxylase , endocrinology , medicine , biochemistry , chemistry , amino acid , dopamine

Several criticisms of past attempts to produce experimental phenylketonuria are discussed, and a model that appears to meet these criticisms is presented. This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood. By this method, an experimental subject is produced whose behavioral, neurological, and biochemical characteristics are similar to those of clinical patients with phenylketonuria.

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