Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding | Zendy

Nadao Kinoshita | Zendy; Harry V. Gelboin | Zendy

Open Access

Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding

Author(s) -

Nadao Kinoshita,

Harry V. Gelboin

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.4.824

Subject(s) - pyrene , chemistry , carcinogenesis , anthracene , carcinogen , hydrocarbon , aryl hydrocarbon receptor , enzyme , polycyclic aromatic hydrocarbon , dna , aryl , biochemistry , rna , benzopyrene , benzo(a)pyrene , organic chemistry , gene , transcription factor , alkyl

Aryl hydrocarbon hydroxylase is present and is inducible in mouse skin. 7,8-Benzoflavone, an inhibitor of the enzyme, markedly inhibits tumorigenesis by 7,12-dimethylbenz(a)anthracene, but has either no effect on or stimulates benzo(a)pyrene tumorigenesis. Thus, the role of aryl hydrocarbon hydroxylase appears highly specific for each polycyclic hydrocarbon, in respect to detoxification and/or activation of the hydrocarbon to a carcinogenic form. In parallel studies, we found that 7,8-benzoflavone significantly reduces the amount of 7,12-dimethylbenz(a)anthracene binding to mouse skin DNA, RNA, and protein, and the binding of benzo(a)pyrene to RNA and protein of mouse skin. 7,8-Benzoflavone exhibited a markedly lesser effect on the binding of benzo(a)pyrene to DNA.

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