Open AccessThe Inhibition of Plant and Animal Adenosine 3′:5′-Cyclic Monophosphate Phosphodiesterases by a Cell-Division-Promoting Substance from Tissues of Higher Plant Species
Author(s) -
Henry N. Wood,
Michael C. Lin,
Armin Braun
Publication year - 1972
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.69.2.403
Subject(s) - phosphodiesterase , adenosine , adenylate kinase , cyclase , cyclic adenosine monophosphate , plant cell , adenosine monophosphate , regulator , adcy3 , cell division , biology , biochemistry , adcy6 , cyclic nucleotide phosphodiesterase , microbiology and biotechnology , enzyme , cell , gene , camp dependent pathway , protein kinase a , receptor
One member of a new class of cell-division-promoting factors, that has been given the trivial name of cytokinesin I, is a potent inhibitor of adenosine 3':5'-cyclic monophosphate phosphodiesterases of both plant and animal origin. Since an adenylate cyclase has been demonstrated in this study to be present in plant cells, the results suggest that cytokinesin I may be exerting its biological effects in promoting division in cells of higher plant species as a regulator of adenosine 3':5'-cyclic monophosphate.