Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes | Zendy

George Miller | Zendy; Thomas C. Shope | Zendy; Hermann Lisco | Zendy; Daphne Stitt | Zendy; Muriel B. Lipman | Zendy

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Epstein-Barr Virus: Transformation, Cytopathic Changes, and Viral Antigens in Squirrel Monkey and Marmoset Leukocytes

Author(s) -

George Miller,

Thomas C. Shope,

Hermann Lisco,

Daphne Stitt,

Muriel B. Lipman

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.2.383

Subject(s) - virus , biology , virology , marmoset , epstein–barr virus , antigen , multinucleate , immunofluorescence , haplorhini , herpesviridae , giant cell , cytopathic effect , gammaherpesvirinae , antibody , viral disease , immunology , microbiology and biotechnology , paleontology , genetics

Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence.

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