Activity of Ribosomes Containing 5S RNA with a Chemically Modified 3′-Terminus | Zendy

Stephen R. Fahnestock | Zendy; Michio Nomura | Zendy

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Activity of Ribosomes Containing 5S RNA with a Chemically Modified 3′-Terminus

Author(s) -

Stephen R. Fahnestock,

Michio Nomura

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.2.363

Subject(s) - ribosome , rna , chemistry , biochemistry , periodate , protein biosynthesis , ribose , morpholine , stereochemistry , combinatorial chemistry , enzyme , organic chemistry , gene

Ribosomes containing 5S RNA in which the 3'-terminus has been modified chemically, either by periodate oxidation or by conversion of the terminal ribose to a morpholine derivative, are fully as active in peptidebond formation and polypeptide synthesis as those ribosomes with unmodified 5S RNA. These results exclude models for protein synthesis in which peptidyl-5S RNA is formed as an intermediate.

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