Genetics of Human-Mouse Somatic Cell Hybrids: Linkage of Human Genes for Lactate Dehydrogenase- A and Esterase-A 4 | Zendy

Thomas B. Shows | Zendy

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Genetics of Human-Mouse Somatic Cell Hybrids: Linkage of Human Genes for Lactate Dehydrogenase- A and Esterase-A ₄

Author(s) -

Thomas B. Shows

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.2.348

Subject(s) - biology , genetics , genetic linkage , lactate dehydrogenase , somatic cell , gene , esterase , phenotype , microbiology and biotechnology , chromosome , gene mapping , enzyme , biochemistry

By use of human-mouse somatic cell hybrids, an autosomal gene linkage has been determined for the human loci controlling the phenotypes of lactate dehydrogenase-A (EC 1.1.1.27) and esterase-A4 (EC 3.1.1.2). These structural loci were not linked to the lactate dehydrogenase-B , peptidase-B linkage, the X chromosome, the E17 chromosome, or to nine other enzyme phenotypes examined.

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