Open AccessConformational Relationships Between Analogs of Acetylcholine and Those of Local Anesthetics in Solution
Author(s) -
Alexandros Makriyannis,
R.F. Sullivan,
Henry G. Mautner
Publication year - 1972
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.69.11.3416
Subject(s) - acetylcholine , heteroatom , chemistry , stereochemistry , general anesthetics , nuclear magnetic resonance , biophysics , medicine , anesthesia , biology , pharmacology , anesthetic , organic chemistry , physics , ring (chemistry)
Conformations of analogs of acetylcholine and of related local anesthetics, in which either of the oxygen atoms had been replaced by other heteroatoms, were studied in solution by nuclear magnetic resonance. Several correlations between structure and conformation could be made.