Activation of Epstein-Barr Virus by 5-Bromodeoxyuridine in “Virus-Free” Human Cells | Zendy

Paul J. Gerber | Zendy

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Activation of Epstein-Barr Virus by 5-Bromodeoxyuridine in “Virus-Free” Human Cells

Author(s) -

Paul J. Gerber

Publication year - 1972

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.69.1.83

Subject(s) - virus , bromodeoxyuridine , epstein–barr virus , virology , biology , genome , serial passage , viral transformation , cell culture , gene , cell growth , genetics

Treatment of three human lymphoid cell lines, free of detectable Epstein-Barr virus, with 5-bromodeoxyuridine resulted in activation of virus synthesis in up to 8% of the cells. The induction of infectious virus could be demonstrated by cocultivation experiments with peripheral leukocytes. These studies demonstrated that the entire viral genome may persist in at least a portion of the lymphoid cells.

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