Open AccessConversion-Associated Recombination in Yeast
Author(s) -
D. D. Hurst,
Seymour Fogel,
Robert Mortimer
Publication year - 1972
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.69.1.101
Subject(s) - recombination , gene conversion , centimorgan , genetics , meiosis , saccharomyces cerevisiae , homologous recombination , genetic recombination , biology , flp frt recombination , mitotic crossover , yeast , gene , gene mapping , chromosome
Gene conversion and conversion-associated reciprocal recombination have been studied in variousSaccharomyces cerevisiae hybrids. In a sample of 11,023 unselected meiotic tetrads, 907 conversions were observed at thearg4, thr3, his1 , andSUP6 loci. Of these conversions, 445 (or 49.1%) were associated with reciprocal recombination of bracketing markers no more than 20-centimorgans apart. For conversions of two other loci,his2 andthr1 , for which the bracketing markers were more than 20-centimorgans apart, recombination frequencies were significantly greater than 50%. These findings are discussed in terms of current models of genetic recombination. It is suggested that all meiotic crossing-over is characterized by the recombination events that are associated with conversion.