Open AccessTranslocation of Messenger RNA and “Accommodation” of fMet-tRNA
Author(s) -
Sigrid S. Thach,
Robert E. Thach
Publication year - 1971
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.8.1791
Subject(s) - gtp' , transfer rna , ribosome , messenger rna , nucleotide , 50s , guanosine triphosphate , chemistry , rna , ef tu , p site , biochemistry , chromosomal translocation , biology , microbiology and biotechnology , enzyme , gene
Messenger RNA is moved a distance of approximately three nucleotides in the 5′ direction relative to the ribosome during the translocation of peptidyl-tRNA from the A to the P site. This movement is catalyzed by G factor and is dependent on the hydrolysis of GTP. In contrast, mRNA is not moved during the f2 -catalyzed hydrolysis of GTP that is involved in the activation of ribosome-bound fMet-tRNA. This second type of GTP-dependent reaction has been named “Accommodation”.
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