Open AccessNature and Self-Regulated Synthesis of the Repressor of the hut Operons in Salmonella typhimurium
Author(s) -
Gerald R. Smith,
Boris Magasanik
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.7.1493
Subject(s) - operon , repressor , gene , salmonella , l arabinose operon , biology , lac operon , trp operon , genetics , escherichia coli , bacteria , gene expression
The enzymes mediating histidine utilization, coded by thehut genes, inSalmonella typhimurium are synthesized from two closely-linked operons. Results presented in this paper show that these operons are regulated by a single repressor protein. ThehutC gene, coding for this repressor, is part of one of the operons. Since this same operon is sensitive to the repressor, the repressor apparently represses its own synthesis.