Species-Specific and Interspecific Antigenic Determinants Associated with the Structural Protein of Feline C-Type Virus | Zendy

Stephen Oroszlan | Zendy; Robert J. Huebner | Zendy; Raymond V. Gilden | Zendy

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Species-Specific and Interspecific Antigenic Determinants Associated with the Structural Protein of Feline C-Type Virus

Author(s) -

Stephen Oroszlan,

Robert J. Huebner,

Raymond V. Gilden

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.5.901

Subject(s) - isoelectric focusing , antigen , isoelectric point , feline leukemia virus , sodium dodecyl sulfate , biology , interspecific competition , gel electrophoresis , chemistry , virology , microbiology and biotechnology , biochemistry , genetics , enzyme , paleontology

The group-specific protein of feline leukemia viruses has been isolated by isoelectric focusing. This protein has a molecular weight, calculated from sodium dodecyl sulfate-acrylamide gel electrophoresis, of 25,000 and forms a resolved band in such gels when disrupted virions are analyzed. This protein contains both species-specific antigenic determinants, as well as interspecific cross-reactive determinants, as an integral part of its structure.

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