Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D 3 Metabolically Active in the Intestine | Zendy

Michael F. Holick | Zendy; Heinrich K. Schnoes | Zendy; Hector F. DeLuca | Zendy

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Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D ₃ Metabolically Active in the Intestine

Author(s) -

Michael F. Holick,

Heinrich K. Schnoes,

Hector F. DeLuca

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.4.803

Subject(s) - metabolite , chemistry , trimethylsilyl , vitamin , cholecalciferol , active metabolite , mass spectrometry , biological activity , vitamin d and neurology , biochemistry , ether , chromatography , biology , organic chemistry , endocrinology , in vitro

A biologically active vitamin D3 metabolite (“peak V metabolite”) more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.

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