z-logo
open-access-imgOpen Access
Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D 3 Metabolically Active in the Intestine
Author(s) -
Michael F. Holick,
Heinrich K. Schnoes,
Hector F. DeLuca
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.4.803
Subject(s) - metabolite , chemistry , trimethylsilyl , vitamin , cholecalciferol , active metabolite , mass spectrometry , biological activity , vitamin d and neurology , biochemistry , ether , chromatography , biology , organic chemistry , endocrinology , in vitro
A biologically active vitamin D3 metabolite (“peak V metabolite”) more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here