The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates | Zendy

Robert E. Koch | Zendy

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The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates

Author(s) -

Robert E. Koch

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.4.773

Subject(s) - base pair , base (topology) , dna , chemistry , mutation , substitution (logic) , biology , genetics , crystallography , mathematics , computer science , mathematical analysis , gene , programming language

The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.

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