ε-(γ-Glutamyl)lysine in Fibrin: Lack of Crosslink Formation in Factor XIII Deficiency | Zendy

John J. Pisano | Zendy; J.S. Finlayson | Zendy; Marjorie P. Peyton | Zendy; Yumiko Nagai | Zendy

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ε-(γ-Glutamyl)lysine in Fibrin: Lack of Crosslink Formation in Factor XIII Deficiency

Author(s) -

John J. Pisano,

J.S. Finlayson,

Marjorie P. Peyton,

Yumiko Nagai

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.4.770

Subject(s) - fibrin , lysine , factor xiii , chemistry , biochemistry , factor xiii deficiency , biology , immunology , amino acid

Fibrin clots formed in normal plasma contained about 6 mol of ε-(γ-glutamyl)lysine per mol of fibrin, whereas those formed in plasma from individuals with Factor XIII deficiency contained little or none of this crosslink (0.02-0.64 mol/mol of fibrin). Partial supplementation of the plasma with Factor XIII, at a single concentration tested, commensurately increased the number of crosslinks.

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