Open Accessε-(γ-Glutamyl)lysine in Fibrin: Lack of Crosslink Formation in Factor XIII Deficiency
Author(s) -
John J. Pisano,
J. S. Finlayson,
Marjorie P. Peyton,
Y. Nagai
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.4.770
Subject(s) - fibrin , lysine , factor xiii , chemistry , biochemistry , factor xiii deficiency , biology , immunology , amino acid
Fibrin clots formed in normal plasma contained about 6 mol of ε-(γ-glutamyl)lysine per mol of fibrin, whereas those formed in plasma from individuals with Factor XIII deficiency contained little or none of this crosslink (0.02-0.64 mol/mol of fibrin). Partial supplementation of the plasma with Factor XIII, at a single concentration tested, commensurately increased the number of crosslinks.