Serum Factor Requirements of Normal and Simian Virus 40-Transformed 3T3 Mouse Fibroblasts | Zendy

Dieter Paul | Zendy; Allan Lipton | Zendy; Ingrid Klinger | Zendy

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Serum Factor Requirements of Normal and Simian Virus 40-Transformed 3T3 Mouse Fibroblasts

Author(s) -

Dieter Paul,

Allan Lipton,

Ingrid Klinger

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.3.645

Subject(s) - 3t3 cells , biology , growth factor , simian , microbiology and biotechnology , virus , cell culture , virology , biochemistry , transfection , genetics , receptor

Evidence is presented to show the presence in normal rat serum of four different serum factors essential for growth of 3T3 or SV40-transformed 3T3 mouse fibroblasts: a factor that specifically promotes growth of normal 3T3 cells; two factors that specifically promote growth of transformed 3T3 cells; and a factor that sustains viability of both normal and transformed 3T3 cells in serum-free medium, probably without inducing growth of the cells. These factors are separated and partially purified.

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