The Mechanism of Protein Synthesis Activation After Fertilization of Sea Urchin Eggs | Zendy

Salvatore Metafora | Zendy; L. Felicetti | Zendy; Roberto Gambino | Zendy

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The Mechanism of Protein Synthesis Activation After Fertilization of Sea Urchin Eggs

Author(s) -

Salvatore Metafora,

L. Felicetti,

Roberto Gambino

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.3.600

Subject(s) - ribosome , sea urchin , paracentrotus lividus , human fertilization , protein biosynthesis , ternary complex , biology , messenger rna , biochemistry , microbiology and biotechnology , chemistry , genetics , rna , enzyme , gene

Upon fertilization of Paracentrotus lividus eggs, the ability of their ribosomes to form a ternary complex with poly(U) and phenylalanyl-tRNA is enhanced. In addition, it is possible to extract from ribosomes of the unfertilized egg a protein factor that inhibits polyphenylalanine synthesis by decreasing the binding of mRNA and aminoacyl-tRNA to the ribosomes. The observed increase in the rate of protein synthesis that occurs at fertilization could be accounted for by the removal of this inhibitory protein from the ribosomes.

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