The Leader Sequence from the 5′-Terminus to the A-Protein Initiation Codon in MS2-Virus RNA | Zendy

Rupert De Wächter | Zendy; A. Vandenberghe | Zendy; J. Merregaert | Zendy; Roland Contreras | Zendy; Walter Fiers | Zendy

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The Leader Sequence from the 5′-Terminus to the A-Protein Initiation Codon in MS2-Virus RNA

Author(s) -

Rupert De Wächter,

A. Vandenberghe,

J. Merregaert,

Roland Contreras,

Walter Fiers

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.3.585

Subject(s) - cistron , rna , start codon , biology , ribonuclease , sequence (biology) , stop codon , untranslated region , ribonuclease t1 , guanosine , base pair , nucleotide , genetics , microbiology and biotechnology , rnase p , amino acid , gene

RNA fragments of different chain length, each containing the 5'-terminal guanosine tetraphosphate (pppGp) of bacteriophage-MS2 RNA, have been isolated from partial ribonuclease digests of the viral RNA. The longest fragment overlaps with the ribosomalbinding site of the A-protein cistron. The base sequence has been established for the major part. The results directly confirm that the A-protein cistron is closest to the 5'-terminus. Its initiating (AUG) codon starts at position 130, being preceded by an untranslated sequence of 129 nucleotides.

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