Adenyl Cyclase as a Link between Photon Capture and Changes in Membrane Permeability of Frog Photoreceptors | Zendy

Mark W. Bitensky | Zendy; Ronnie E. Gorman | Zendy; William H. Miller | Zendy

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Adenyl Cyclase as a Link between Photon Capture and Changes in Membrane Permeability of Frog Photoreceptors

Author(s) -

Mark W. Bitensky,

Ronnie E. Gorman,

William H. Miller

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.3.561

Subject(s) - darkness , biophysics , permeability (electromagnetism) , retina , cyclase , electrophysiology , chemistry , retinal , receptor , membrane potential , membrane , sodium , biology , microbiology and biotechnology , biochemistry , neuroscience , botany , organic chemistry

Tomita has shown by electrophysiological measurements that the photoreceptors of the vertebrate retina are depolarized (excited) by darkness and hyperpolarized (inhibited) by light. Excitation is accompanied by an increase, and inhibition by a decrease, in the sodiumion permeability of the receptor cell. The retinal-rod outer segments of the frog contain an adenyl cyclase that is active in darkness and inactivated by light. This cyclase has a specific activity ten-times higher than the activity in previously described tissues. It is suggested that cyclic AMP is an intermediate in the light- and dark-induced changes in sodium permeability in the photoreceptor cell.

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