Enhanced Immunogenicity of Chemically-Coated Syngeneic Tumor Cells | Zendy

Martin Wj | Zendy; John R. Wunderlich | Zendy; Freeman Fletcher | Zendy; John K. Inman | Zendy

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Enhanced Immunogenicity of Chemically-Coated Syngeneic Tumor Cells

Author(s) -

Martin Wj,

John R. Wunderlich,

Freeman Fletcher,

John K. Inman

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.2.469

Subject(s) - immunogenicity , concanavalin a , in vitro , immune system , cytotoxicity , leukemia , neoplasm , chemistry , microbiology and biotechnology , biology , immunology , cancer research , biochemistry , genetics

The immunogenicity of the EL-4 strain of mouse lymphoid leukemia cells in syngeneic C57BL/6 recipients was enhanced by in vitro coating of the cells with either Concanavalin A or dinitrophenylaminocaproate. The tumor-specific immune response was quantitated using a recently developed assay that involves in vitro cell-mediated cytotoxicity.

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