Induced Degradation of Glycosaminoglycans in Hurler's and Hunter's Syndromes by Plasma Infusion | Zendy

Nicola Di Ferrante | Zendy; Buford L. Nichols | Zendy; Patricia V. Donnelly | Zendy; Giovanni Neri | Zendy; Ruzica Hrgovcic | Zendy; Robert K. Berglund | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Induced Degradation of Glycosaminoglycans in Hurler's and Hunter's Syndromes by Plasma Infusion

Author(s) -

Nicola Di Ferrante,

Buford L. Nichols,

Patricia V. Donnelly,

Giovanni Neri,

Ruzica Hrgovcic,

Robert K. Berglund

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.2.303

Subject(s) - dermatan sulfate , glycosaminoglycan , heparan sulfate , hunter syndrome , chemistry , excretion , endocrinology , medicine , sulfate , human plasma , degradation (telecommunications) , biochemistry , chromatography , telecommunications , organic chemistry , computer science

The effects of the administration of normal human plasma to patients affected by mucopolysaccharidoses I and II (Hurler's and Hunter's syndromes) have been evaluated. The infusion was followed by a decreased urinary excretion of relatively large molecular weight glycosaminoglycans and by an increased excretion of their products of degradation. Among the latter, products of the degradation of dermatan sulfate and heparan sulfate could be demonstrated. The results indicate that normal human plasma may contain those "factors" that are involved in the normal degradation of dermatan sulfate and heparan sulfate, that are missing in the diseased states.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research