Interferon and Transcription of Early Virus-Specific RNA in Cells Infected with Simian Virus 40 | Zendy

Michael N. Oxman | Zendy; Myron J. Levin | Zendy

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Interferon and Transcription of Early Virus-Specific RNA in Cells Infected with Simian Virus 40

Author(s) -

Michael N. Oxman,

Myron J. Levin

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.2.299

Subject(s) - transcription (linguistics) , interferon , biology , virus , virology , rna , simian , gene , messenger rna , genetics , philosophy , linguistics

Treatment with interferon reduced the content of early virus-specific RNA, as well as the content of an early viral protein (T antigen), in monkey cells acutely infected with simian virus 40 (SV40). This unexpected finding suggests either that the action of interferon involves inhibition of the transcription of early SV40 messenger RNA, or that the SV40 genome contains a "proto-early" gene whose product is required for the transcription of the remaining early genes.

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