Mechanism of Action of Thrombin on Fibrinogen, I. Synthesis of Fibrinogen-like Peptides, and Their Proteolysis by Thrombin and Trypsin | Zendy

Rudolf H. Andreatta | Zendy; Ronald K.H. Liem | Zendy; Harold A. Scheraga | Zendy

Open Access

Mechanism of Action of Thrombin on Fibrinogen, I. Synthesis of Fibrinogen-like Peptides, and Their Proteolysis by Thrombin and Trypsin

Author(s) -

Rudolf H. Andreatta,

Ronald K.H. Liem,

Harold A. Scheraga

Publication year - 1971

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.68.2.253

Subject(s) - thrombin , fibrinogen , trypsin , proteolysis , chemistry , biochemistry , glycine , enzyme , oligopeptide , mechanism of action , peptide , amino acid , biology , platelet , in vitro , immunology

In a study of the action of thrombin on fibrinogen and a comparison of this enzyme with trypsin, several fibrinogen-like oligopeptides were synthesized. The hydrolysis of the arginyl-glycine bond in these peptides, by both of these enzymes, is examined and compared.

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