Open AccessStudies on Phosphorylation by Phosphoroguanidinates. The Mechanism of Action of Creatine: ATP Transphosphorylase (Creatine Kinase)
Author(s) -
Paul Haake,
Gary W. Allen
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.11.2691
Subject(s) - creatine , creatine kinase , mechanism of action , phosphorylation , phosphate , metaphosphate , chemistry , phosphocreatine , biochemistry , mechanism (biology) , kinase , biology , endocrinology , energy metabolism , philosophy , epistemology , in vitro
The solvolyses of phosphorocreatine (creatine phosphate) and models for phosphorocreatine have been investigated and the results are applied to the mechanism of action of creatine kinase (EC 2.7.3.2). A metaphosphate intermediate appears to be involved.