Open AccessAmino Acid Sequence of the Light Chain from a Mouse Myeloma Protein with Anti-Hapten Activity: Evidence for a Third Type of Light Chain
Author(s) -
Elizabeth P. Schulenburg,
Ernest S. Simms,
Richard G. Lynch,
Ralph A. Bradshaw,
Herman N. Eisen
Publication year - 1971
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.11.2623
Subject(s) - immunoglobulin light chain , hapten , myeloma protein , amino acid , peptide sequence , chain (unit) , biochemistry , antibody , chemistry , sequence (biology) , dinitrophenyl , bence jones protein , biology , microbiology and biotechnology , genetics , gene , physics , astronomy
A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The “variable” segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.